The Barossa Valley is a pretty safe area. The usual travel precautions always apply though.
You should be very careful not to drink and drive. The police are very vigilant as this region sadly has a high rate of car accident deaths amongst young males - the roads can be very windy and large gum trees in these region often front onto the road, which can make coming at one very daunting as you round a corner. Stick to the speed limits and keep safe.
major towns
Nuriootpa
Tanunda
Lyndoch
Angaston